Active - Stage 2Atlas Opportunity Score 58/100
HHS ARPA-H 2026 SBIR/STTR Small Business Program — 7599226SN106
FundingARPA-H small-business awards are generally contracts up to $600,000 for Phase 1 and $3.5 million for Phase 2; exact award depends on the solicitation, topic and milestone performance.
DeadlineSeptember 16, 2026 at 5:00 PM ET for Topics 1, 2, 3, 4, 6, and 7; October 1, 2026 at 12:00 PM ET for Topic 5. Prior successful Stage 1 participation is required for the applicable topic.
Last verifiedSeptember 15, 2026
Required next actionVerify applicant-specific Stage 1 submission/encouragement, the controlling BAA cover page, topic fit, Stage 2 requirements, budget, registrations and submission instructions before pursuing. Do not treat this as a new-entry Stage 2 opportunity.
Broad Eligibility
Qualified U.S. small business concerns meeting SBIR statutory ownership/control requirements and having no more than 500 employees including affiliates. Current Stage 2 participation is tied to the solicitation's earlier Stage 1 Solution Summary process and encourage/discourage letters.
Atlas Analysis
This opportunity is limited to qualified U.S. small businesses pursuing one of ARPA-H's seven FY2026 SBIR/STTR topics through the staged process. Current Stage 2 materials for Topics 1, 2, 3, 4, 6, and 7 are due September 16, 2026 at 5:00 PM ET, while Topic 5 materials are due October 1, 2026 at 12:00 PM ET. Applicants should confirm that they completed the applicable Stage 1 Solution Summary process and received the required encouragement before preparing Stage 2 materials, then follow the current ARPA-H solicitation, FAQs, and submission instructions.
The HHS Advanced Research Projects Agency for Health (ARPA-H) is soliciting qualified small businesses under its FY2026 Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) program, solicitation 7599226SN106. The current solicitation covers seven research topics spanning fertility diagnostics, versatile bioadhesives, a synthetic-biology toxin-removal platform, non-surgical endometriosis therapy, commercialization of technologies originating from ARPA-H-funded work, rapid multi-system autoimmune diagnostics, and a virtual human brain for neurosurgical robotics.
ARPA-H’s current small-business program page shows Stage 2 materials due September 16, 2026 at 5:00 PM ET for Topics 1, 2, 3, 4, 6, and 7, and October 1, 2026 at 12:00 PM ET for Topic 5. The solicitation is a Total Small Business Set-Aside under NAICS 541715. SBIR applicants must meet the program’s U.S. small-business ownership and control rules and have no more than 500 employees including affiliates. ARPA-H states that its small-business awards are generally issued as contracts of up to $600,000 for Phase 1 and $3.5 million for Phase 2, with continued funding dependent on milestone performance.
This opportunity is no longer an unrestricted new-entry window. Amendment 01 extended Stage 1 Solution Summaries to July 17, 2026. Amendment 02 established Stage 2 timing for Topics 01, 02, 03, 04, 06, and 07 after Stage 1 encourage/discourage letters, and Amendment 03 established the Topic 05 Stage 2 timing after its Stage 1 letters. An organization should not treat the October 1 date as permission to enter at Stage 2 without having completed the applicable earlier Stage 1 process. The current topic set is highly specialized, so applicants should pursue only a topic for which they can document the required technical fit and verified prior Stage 1 status.
Source verificationOfficial government source · sam.govAtlas last verified this record September 15, 2026. Always use the funder's current application materials, amendments and portal instructions as the controlling source.View source and application materials ↗
