NIH Intervention Research to Improve Native American Health (R01 Clinical Trial Optional) — PAR-25-379
Issuer: National Institutes of Health (NIH), Intervention Research to Improve Native American Health (IRINAH) initiative
Deadline: October 21, 2026 at 5:00 p.m. local time of the applicant organization.
Funding: Application budgets are not limited but must reflect the actual needs of the proposed project. Applicants requesting $500,000 or more in direct costs in any year, excluding consortium F&A, must follow NIH’s additional instructions. The total project period may not exceed five years. No cost sharing is required.
Hawaiʻi relevance: NIH expressly includes Native Hawaiian communities within the populations covered by this NOFO. The R01 supports rigorous community-engaged research on interventions to improve health in Native populations, including etiologic research that directly informs interventions, development/adaptation/testing of health-promotion, prevention, treatment or recovery interventions, and dissemination/implementation research.
Community engagement is mandatory
Research must be conducted in a community-engaged manner in which the Native community has an equal voice as a research partner and is appropriately involved in study design and the overall approach. Community-based participatory research is encouraged where desired by the community. Applications that do not propose a community-engaged project are nonresponsive.
Eligible organizations and registrations
Eligible organizations include public and private higher-education institutions, 501(c)(3) and other nonprofits, for-profit organizations and small businesses, state and local governments, Native organizations, community-based organizations, regional organizations, and other listed domestic entities. Foreign organizations are not eligible.
Applicant organizations must have active SAM/UEI, eRA Commons, and Grants.gov registrations in place before submission. PD/PI personnel must have eRA Commons accounts. NIH cautions that organizational registrations can take six weeks or more.
Hawaiʻi applicant fit
University of Hawaiʻi at Mānoa / John A. Burns School of Medicine is a strong conditional applicant candidate. JABSOM’s Department of Native Hawaiian Health is specifically dedicated to Native Hawaiian health and integrates research, community engagement, clinical care, and education. Its Center for Native and Pacific Health Research reports more than a decade of continuous NIH funding for biomedical and behavioral research, and its community-engagement infrastructure supports trust-based partnerships with Native Hawaiian and Pacific Islander communities. Final pursuit requires a specific qualified PD/PI, scientifically mature R01 aims, the appropriate participating NIH Institute or Center, a Native Hawaiian community research partnership with equal voice, current federal registrations, institutional approval, final study design, data-management/sharing plans, and human-subjects or clinical-trial documentation as applicable.
Atlas assessment
Atlas Opportunity Score: 99/100
UH Mānoa / JABSOM Applicant Fit: 98/100 conditional
N9+ Fit Score: 15/100 conditional — a remote physical-examination platform may be relevant only if it is integral to a scientifically justified intervention involving guided examinations, vitals, or telehealth-enabled clinical encounters. This is not an equipment-purchase program, and technology should not be forced into the research objective.
QC Healthcare Fit: 50/100 conditional — applicant-led research design, implementation, workflow, training, quality-improvement, or evaluation support may fit when scientifically appropriate and allowable.
Dr. Miltie direct applicant: Not advanced. Although for-profit organizations are eligible, Atlas has not verified the NIH research infrastructure, qualified PD/PI, Native Hawaiian community partnership, or federal research administration required for a defensible direct R01 application.
Official sources: NIH PAR-25-379 | JABSOM Department of Native Hawaiian Health | JABSOM Research Centers