Verification Pending — official Grants.gov candidate (posted)
PAR-25-374
Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)
Official Grants.gov opportunity PAR-25-374 from National Institutes of Health. Requires full eligibility, amount, controlling deadline, award-type and duplication QA before publication.
FundingOfficial federal synopsis lists an award ceiling of 1,000,000; applicant-level applicability requires full-NOFO review.
Deadline2028-05-07 (official deadline clock time and time zone must be checked in NOFO)
Last verifiedAtlas review
Required next actionReview the official full announcement, amendments and submission portal requirements before applying.
Broad Eligibility
Small businesses; Public and State controlled institutions of higher education; Independent school districts; For profit organizations other than small businesses; State governments; Special district governments; City or township governments; Native American tribal governments (Federally recognized); Private institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: PAR-25-374
Official listed status: posted
Closing information: 2028-05-07 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Official federal synopsis lists an award ceiling of 1,000,000; applicant-level applicability requires full-NOFO review.
Applicant categories in federal synopsis: Small businesses; Public and State controlled institutions of higher education; Independent school districts; For profit organizations other than small businesses; State governments; Special district governments; City or township governments; Native American tribal governments (Federally recognized); Private institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Federal synopsis
This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.
Official Grants.gov opportunity and NOFO
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Source verificationOfficial government source · www.grants.govAtlas last verified this record during its latest review. Always use the funder's current application materials, amendments and portal instructions as the controlling source.View source and application materials ↗
