Statewide Texas cancer-prevention funding opportunity. The Cancer Prevention and Research Institute of Texas (CPRIT) has released RFA P-27.2-PPC, Primary Prevention of Cancer, for FY2027 Cycle 2. CPRIT lists the RFA as open, with applications accepted through its new Grants Management Platform beginning September 16, 2026 at 7:00 AM Central Time and due December 8, 2026 at 5:00 PM Central Time.
Funding: maximums apply across the full grant period and include direct and indirect costs. New Projects and Initial Expansions may request up to $1 million for up to 3 years. Initial Expansions focused on adult vaccination or tobacco cessation may request up to $1.5 million for up to 3 years. Maintenance Expansions may request up to $2 million for up to 5 years, or up to $2.5 million for up to 5 years when focused on adult vaccination or tobacco cessation.
Purpose and required model: projects must implement evidence-based, multilevel interventions that reduce modifiable cancer risks and disparities. Supported focus areas include tobacco use, obesity, physical inactivity, unhealthy eating, alcohol use, sun exposure, HPV vaccination, hepatitis B vaccination, and environmental or occupational cancer exposures. All applications must include delivery of clinical services. CPRIT identifies examples such as vaccinations, counseling, diagnostic tests, clinical assessments, physical-activity or rehabilitation services, nutrition services, tobacco-cessation services, case management, and other evidence-based preventive services delivered by qualified health professionals.
Geography and populations: the applicant must be Texas-based. Projects must include preventive service delivery to medically underserved areas, medically underserved populations, and/or other priority populations, with strong emphasis on cancer disparities, access barriers, and social determinants of health. Collaborative partnerships are strongly encouraged.
Eligible applicants: Texas-based entities may include community-based organizations, health institutions, government organizations, public or private companies, colleges or universities, and academic health institutions. The Program Director must have relevant education and management experience and reside in Texas during the project. Project evaluation must be led by a qualified professional who also resides in Texas during the project. Collaborators may be located outside Texas, but non-Texas organizations cannot receive CPRIT funds.
Allowable costs: grant funds may support clinical services, education, navigation, salary and benefits, supplies, equipment, outreach/education costs, project travel, contractual expenses, service agreements, software, internet services, and related project costs when justified. Equipment with a useful life over one year and acquisition cost of $10,000 or more per unit requires specific CPRIT approval; cost sharing for equipment is strongly encouraged but the RFA does not establish a general mandatory match requirement. Indirect/shared costs are capped at 5% of the total award.
Key restrictions: construction, renovation, infrastructure, lobbying, cancer treatment itself, and international travel are not funded. CPRIT will fund diagnostic testing and navigation into cancer treatment, but not the treatment. Food itself is not reimbursable. CPRIT seeks to fill funding gaps and prohibits supplanting existing funding.
Expansion controls: expansion applicants must demonstrate significant growth in geography and/or services. Initial expansion projects must extend services to nonmetropolitan rural areas, medically underserved populations, and/or medically underserved counties. Applicants may submit no more than one new-project application and up to one expansion application in the cycle, and duplicative applications may be administratively withdrawn.
Submission: applications must be submitted online through CPRIT’s new Grants Management Platform. CPRIT states that the FY27 Cycle 2 Instructions for Applicants will be added when available, so applicants should recheck the official funding page and GMP at opening before finalizing a package.
Atlas Opportunity Score: 94/100. This is a high-value, statewide Texas prevention mechanism with broad applicant eligibility, meaningful funding, a long preparation runway, explicit clinical-service requirements, and allowance for justified equipment, software, contractual services, and technology-supported interventions.
N9+ Fit: 42/100, conditional applicant-led fit. N9+ should not be presented as a cancer-prevention intervention by itself. A legitimate role may exist where a qualified Texas applicant uses remote guided physical examination or clinical assessment as a documented component of an evidence-based multilevel prevention or survivorship program, and where the applicant establishes that the technology is necessary, allowable, and appropriately integrated with required clinical services. Equipment at or above CPRIT’s approval threshold requires specific CPRIT approval. QC Healthcare support could be relevant only when a qualified applicant has a verified clinical-service need and all staffing, licensure, evidence-base, and budget requirements are independently satisfied.
Official sources: CPRIT Funding Opportunities and RFA P-27.2-PPC.