Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: RFA-HG-27-007
Official listed status: posted
Closing information: 2026-12-14 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Official federal synopsis lists an award ceiling of 2,000,000; applicant-level applicability requires full-NOFO review.
Applicant categories in federal synopsis: Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal governments (Federally recognized); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Independent school districts; Private institutions of higher education; Public and State controlled institutions of higher education; Special district governments; State governments; City or township governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Federal synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.