Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: PAR-25-025
Official listed status: posted
Closing information: 2027-01-07 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Official federal synopsis lists an award ceiling of 1,515,000; applicant-level applicability requires full-NOFO review.
Applicant categories in federal synopsis: Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Special district governments; State governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Private institutions of higher education; City or township governments; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Public and State controlled institutions of higher education; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public housing authorities/Indian housing authorities
Federal synopsis
The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. The proposed trial can be single or multisite. Applicants applying for funding under this NOFO should be ready to initiate the clinical trial within the first quarter of the project period. Discussion, submission, and attainment of applicable regulatory (FDA, DSMB, IRB) approvals, and establishment of drug (and placebo, if applicable) supplies, and any necessary third-party agreements should be established by the time of award. If time and support for these and other pre-clinical and/or trial readiness activities are desired, applicants should consider the companion NOFO which utilizes an R61/R33 phased approach.
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.