National Cancer Institute’s Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)

Official funding announcement — preliminary draft

Funder: National Institutes of Health

Opportunity number: PAR-25-081

Official listed status: posted

Closing information: 2027-01-07 (official deadline clock time and time zone must be checked in NOFO)

Award disclosure: Official federal synopsis lists an award ceiling of 499,999; applicant-level applicability requires full-NOFO review.

Applicant categories in federal synopsis: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; City or township governments; Private institutions of higher education; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal governments (Federally recognized); Small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Independent school districts; For profit organizations other than small businesses

Federal synopsis

Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.

Official Grants.gov opportunity and NOFO