Verification Pending — official Grants.gov candidate (posted)
PAR-25-446
Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 – Clinical Trial Optional)
Official Grants.gov opportunity PAR-25-446 from National Institutes of Health. Requires full eligibility, amount, controlling deadline, award-type and duplication QA before publication.
FundingOfficial federal synopsis lists an award ceiling of 3,000,000; applicant-level applicability requires full-NOFO review.
Deadline2028-08-21 (official deadline clock time and time zone must be checked in NOFO)
Last verifiedAtlas review
Required next actionReview the official full announcement, amendments and submission portal requirements before applying.
Broad Eligibility
County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Special district governments; Private institutions of higher education; For profit organizations other than small businesses; State governments; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; City or township governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education
Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: PAR-25-446
Official listed status: posted
Closing information: 2028-08-21 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Official federal synopsis lists an award ceiling of 3,000,000; applicant-level applicability requires full-NOFO review.
Applicant categories in federal synopsis: County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Special district governments; Private institutions of higher education; For profit organizations other than small businesses; State governments; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; City or township governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education
Federal synopsis
The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.
Official Grants.gov opportunity and NOFO
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Source verificationOfficial government source · www.grants.govAtlas last verified this record during its latest review. Always use the funder's current application materials, amendments and portal instructions as the controlling source.View source and application materials ↗
