Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: RFA-RM-27-016
Official listed status: posted
Closing information: 2026-11-23 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Applicant-level ceiling not stated in the retrieved federal synopsis; verify in full NOFO.
Applicant categories in federal synopsis: Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Small businesses; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts; Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education; Native American tribal governments (Federally recognized); Special district governments; State governments; City or township governments; Public and State controlled institutions of higher education
Federal synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to support SenNet Discovery and Validation Centers (SenNet DVCs) as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network (SenNet). Building on Stage 1 resources, DVCs will define, refine, and validate tissue- and disease-relevant cellular senescence signatures (“senotypes”) and associated biomarkers, and will investigate their functional consequences in human health and disease. DVCs are expected to generate and contribute high-quality molecular, cellular, and spatial datasets (including relevant metadata and documentation) and to use complementary experimental systems, as appropriate, to validate senotypes/biomarkers and characterize responses to senescence-associated perturbations or senotherapeutic approaches. DVC applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities (SenNet OOC functions).
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.