Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

Official funding announcement — preliminary draft

Funder: National Institutes of Health

Opportunity number: PAR-25-442

Official listed status: posted

Closing information: 2028-02-17 (official deadline clock time and time zone must be checked in NOFO)

Award disclosure: Applicant-level ceiling not stated in the retrieved federal synopsis; verify in full NOFO.

Applicant categories in federal synopsis: Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Native American tribal organizations (other than Federally recognized tribal governments); County governments; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Public housing authorities/Indian housing authorities; State governments; Special district governments; For profit organizations other than small businesses; Native American tribal governments (Federally recognized); Private institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments

Federal synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.

Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.

Official Grants.gov opportunity and NOFO