Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: PAR-25-352
Official listed status: posted
Closing information: 2027-10-25 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Applicant-level ceiling not stated in the retrieved federal synopsis; verify in full NOFO.
Applicant categories in federal synopsis: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; Native American tribal governments (Federally recognized); For profit organizations other than small businesses; City or township governments; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; Private institutions of higher education; County governments; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Public and State controlled institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities
Federal synopsis
Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies Projects seeking support for a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach should consider the companion U19 FOA.
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.