Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 – Clinical Trial Optional)

Official funding announcement — preliminary draft

Funder: National Institutes of Health

Opportunity number: PAR-25-266

Official listed status: posted

Closing information: 2027-11-16 (official deadline clock time and time zone must be checked in NOFO)

Award disclosure: Official federal synopsis lists an award ceiling of 200,000; applicant-level applicability requires full-NOFO review.

Applicant categories in federal synopsis: County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); City or township governments; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; Independent school districts; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Special district governments; Small businesses; Public and State controlled institutions of higher education

Federal synopsis

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.

Official Grants.gov opportunity and NOFO