Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: PAR-25-267
Official listed status: posted
Closing information: 2026-11-17 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Official federal synopsis lists an award ceiling of 350,000; applicant-level applicability requires full-NOFO review.
Applicant categories in federal synopsis: Independent school districts; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; Small businesses; City or township governments; For profit organizations other than small businesses; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; County governments; Private institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification)
Federal synopsis
This notice of funding opportunity (NOFO) invites applications for investigator-initiated clinical trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) in NCCIH-designated areas of high research priority. Applications submitted under this NOFO are expected to propose a multisite feasibility clinical trial that will provide new information that is scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R01) research is scientifically necessary to design or plan the subsequent fully powered, full-scale clinical trial. Under this R01, the data collected should be used to fill gaps in scientific knowledge, including, but not limited to the following: assessing whether the intervention can be delivered with fidelity across sites; demonstrating feasibility of recruitment, accrual, and randomization of participants across sites; demonstrating participant adherence to the intervention, as well as retention of participants throughout the study across sites; refining and assessing the feasibility of protocolized multimodal interventions, and/or demonstrating feasibility of data collection across sites in preparation for a future fully powered, multisite efficacy or effectiveness trial. The need for multisite feasibility trials is expected to be justified by sufficient preliminary data from previous single site …
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.