Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Official funding announcement — preliminary draft

Funder: National Institutes of Health

Opportunity number: PAR-25-122

Official listed status: posted

Closing information: 2027-11-16 (official deadline clock time and time zone must be checked in NOFO)

Award disclosure: Official federal synopsis lists an award ceiling of 100,000; applicant-level applicability requires full-NOFO review.

Applicant categories in federal synopsis: Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); Small businesses; County governments; Private institutions of higher education; Independent school districts; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Special district governments; Native American tribal organizations (other than Federally recognized tribal governments); State governments; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Federal synopsis

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.

Official Grants.gov opportunity and NOFO