Official funding announcement — preliminary draft
Funder: National Institutes of Health
Opportunity number: PAR-25-311
Official listed status: posted
Closing information: 2027-11-15 (official deadline clock time and time zone must be checked in NOFO)
Award disclosure: Official federal synopsis lists an award ceiling of 6,250,000; applicant-level applicability requires full-NOFO review.
Applicant categories in federal synopsis: Public housing authorities/Indian housing authorities; Independent school districts; Small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; County governments; Private institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); City or township governments; Public and State controlled institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Native American tribal governments (Federally recognized)
Federal synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research Network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.
Draft intake record. Eligibility, program terms, current amendments and applicant ceiling must be independently verified before publishing.