The National Institutes of Health is accepting R01 applications under PAR-26-001, Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities. Participating NIH components include ODP, NIAAA, NIDCR, NIDA, NIMHD, and NCI, with ORWH potential co-funding.
Next new-application deadline: October 5, 2026 at 5:00 PM local time of the applicant organization. The next renewal/resubmission deadline is November 5, 2026 at 5:00 PM applicant-local time. The NOFO expires May 8, 2027.
Funding: Application budgets are not capped but must reflect the actual needs of the proposed project. The maximum project period is five years. Cost sharing is not required.
Eligibility: Eligible organizations include public and private higher education, nonprofits, small businesses and other for-profit organizations, state and local governments, independent school districts, tribal entities, eligible federal agencies, faith/community organizations, and other listed domestic organization types. Required registrations include SAM, Grants.gov, and eRA Commons.
Research requirements: This is a clinical-trial-required R01. Projects must prospectively test SBIRT/P for alcohol, tobacco, or other drug use or misuse in adult NIH-designated populations experiencing health disparities. Applications must identify the population and relevant SBIRT/P disparity or barrier, address sustainability or scalability, describe healthcare and community partner roles, and provide an appropriate multi-level analytic plan. Projects that do not focus on a qualifying health-disparity population or do not prospectively test SBIRT/P are nonresponsive.
Technology and rural fit: NIAAA specifically encourages evaluation of new technologies that improve adoption, implementation, and sustainability of SBIRT/P, including in rural, remote, and under-resourced communities. The NOFO also supports organizational and multi-sector approaches, non-traditional settings, and interventions addressing co-occurring behavioral or health risks.
Submission: Applications are submitted through NIH ASSIST, Grants.gov Workspace, or an institutional system-to-system solution and tracked in eRA Commons. Applicants requesting $500,000 or more in direct costs in any year, excluding consortium F&A, should follow NIH prior-contact requirements.
Atlas fit: Strong Arkansas behavioral-health and rural-health research opportunity. Atlas Opportunity Score: 93/100. N9+ Fit Score: 76/100, conditional. A defensible N9+ role would be as a structured remote-assessment, physiologic/vitals, or connected-health data layer within an investigator-led SBIRT/P implementation trial where those measurements materially improve screening, engagement, referral, follow-up, or rural access. N9+ should not be presented as the SBIRT/P intervention itself or as a stand-alone equipment purchase. Although for-profit organizations are formally eligible, a direct Dr. Miltie prime should not advance without R01-scale clinical-trial leadership, appropriate research partners, NIH registrations, and a fully responsive study design. An academic-led collaboration or technology subcontract is the stronger pathway.