NIH is accepting R01 applications under PAR-25-317, Risk and Protective Factors of Family Health and Family Level Interventions. The opportunity supports family-level observational and intervention research in biomedical, clinical, population, behavioral, and social sciences, with a required focus on families from one or more NIH-designated populations experiencing health disparities in the United States.
Next new-application deadline: October 5, 2026 at 5:00 PM local time of the applicant organization. The NOFO remains open for later standard cycles through May 8, 2027.
Funding: Application budgets are not limited but must reflect the actual needs of the proposed project. The maximum project period is five years. Cost sharing is not required.
Eligibility: Eligible organization classes include public and private institutions of higher education, nonprofits, small businesses and other for-profit organizations, state and local governments, independent school districts, tribal governments and organizations, faith- and community-based organizations, regional organizations, and other listed domestic entities. Required SAM, Grants.gov, and eRA Commons registrations must be active before submission.
Program requirements: Projects are expected to include family health outcome or behavior measures for at least two family members and must focus on families from NIH-designated populations experiencing health disparities in the United States. The NOFO supports observational and intervention studies and encourages multidisciplinary approaches spanning biological, behavioral, sociocultural, environmental, neighborhood, organizational, and health-services influences. Clinical trials are optional.
Technology relevance: The NOFO recognizes technology and other resources as potential tools to promote and protect family health. For Arkansas applicant pathways, the Nonagon N9+ may be relevant only where guided remote examination, home-based objective measures, vitals, caregiver-child assessment, telehealth data, or connected-health workflows are scientifically material to the applicant-led study. N9+ should not be positioned as the family intervention itself.
Atlas fit: High-value applicant-led research opportunity for experienced family-health and health-disparities teams. A realistic Dr. Miltie posture is technology collaborator or subcontractor where the study design independently justifies remote objective clinical data collection or connected-health workflow support.