The National Center for Complementary and Integrative Health (NCCIH), part of NIH, is accepting R01 applications under PAR-25-268, Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth. The program supports fully remote, adequately powered clinical trials evaluating the efficacy or effectiveness of complementary and integrative health interventions in NCCIH-designated high-priority areas.
Next application deadline: October 20, 2026 at 5:00 PM local time of the applicant organization. Assistance Listing: 93.213. The NOFO expires November 18, 2026.
Funding: Application budgets are not limited but must reflect the actual needs of the proposed project. The maximum project period is five years. The number of awards depends on NIH appropriations and the number of meritorious applications. Cost sharing is not required.
Eligibility: Eligible domestic applicants include small businesses and other for-profit organizations, public and private institutions of higher education, nonprofits, state and local governments, independent school districts, tribal entities, eligible federal agencies, public housing authorities, community organizations, and regional organizations. Foreign organizations are not eligible, although permitted foreign components may be allowed under NIH policy. Required registrations include SAM/UEI, Grants.gov, and eRA Commons.
Program requirements: The proposed clinical trial must be fully remotely delivered and conducted, with no in-person contact between research staff and participants. NCCIH expressly contemplates phone, app, video, web, wearable, and other mHealth technologies for remote intervention delivery and data collection. Applicants must justify the remote approach, provide required preliminary feasibility and safety data, and demonstrate a team with relevant remote clinical-trial experience. Trials must be geographically distributed rather than limited to one city or region.
NCCIH identifies health care systems, schools, Federally Qualified Health Centers, military or veteran health care delivery organizations, community organizations, justice systems, and homeless shelters as examples of relevant settings when the scientific rationale supports integration into care. High-priority outcomes include health behaviors, sleep, depression, anxiety, chronic stress, post-traumatic stress, obesity, pain, whole-person health, maternal-health disparities, and related areas.
Atlas fit: High, but collaboration-oriented. The Nonagon N9+ can legitimately support a qualifying project as an existing remote physical examination platform that supplies guided examinations, vitals, telehealth-enabled clinical encounter capability, remote safety monitoring, or objective physiologic outcome data when those functions materially support the complementary or integrative intervention and study aims. N9+ should not be forced into the role of the complementary intervention itself. Dr. Miltie is technically within an eligible for-profit applicant class, but a TRUE direct submission should not advance without the qualified PI/research team, required preliminary human data, proven remote-trial experience, appropriate comparator, and any needed FDA/IDE determination. The strongest pathway is a partner-led clinical-trial collaboration or technology subcontract with an experienced research organization.